Modulation of myocardial function and [Ca21] sensitivity by moderate hypothermia in guinea pig isolated hearts
نویسندگان
چکیده
form (R. A. Paulsen, S. Fujita, S. C. Smart, and D. F. Stowe. FASEB J. 11: A526, 1997). Present address of S. Fujita: Dept. of Anesthesiology, Minami 1-Jyo Hospital, S-1, W-13, Chuo-ku, Sapporo Medical University, Hokkaido 060, Japan. Address for reprint requests and other correspondence: D. F. Stowe, M4280 MEB, 8701 Watertown Plank Rd., Medical College of Wisconsin, Milwaukee Regional Medical Center, Milwaukee, WI 53226 (E-mail: [email protected]). Received 1 March 1999; accepted in final form 14 June 1999.
منابع مشابه
Modulation of myocardial function and [Ca2+] sensitivity by moderate hypothermia in guinea pig isolated hearts.
Cardiac hypothermia alters contractility and intracellular Ca2+ concentration ([Ca2+]i) homeostasis. We examined how left ventricular pressure (LVP) is altered as a function of cytosolic [Ca2+]iover a range of extracellular CaCl2 concentration ([CaCl2]e) during perfusion of isolated, paced guinea pig hearts at 37°C, 27°C, and 17°C. Transmural LV phasic [Ca2+] was measured using the Ca2+ indicat...
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